Methadone ain’t good for you

I know that this would seem obvious, but Methadone has been used for years to help get folks who are addicted to narcotics get off of narcotics. It was used as a bridge.  Well, it seems that the methadone bridge isn’t safe. A recent study looked at patients taking methadone verses long-acting morphine. The patients taking methadone for noncancer pain had a higher rate of death. I know that I have some trauma patients who have tons of pain. I really haven’t used methadone except in those patients who were on methadone prior to their trauma. Exactly how to treat patients with tons of pain isn’t really all that clear in the literature. At least it isn’t clear to me.


Importance  Growing methadone use in pain management has raised concerns regarding its safety relative to other long-acting opioids. Methadone hydrochloride may increase the risk for lethal respiratory depression related to accidental overdose and life-threatening ventricular arrhythmias.

Objective  To compare the risk of out-of-hospital death in patients receiving methadone for noncancer pain with that in comparable patients receiving sustained-release (SR) morphine sulfate.

Design, Setting, and Participants  A retrospective cohort study was conducted using Tennessee Medicaid records from 1997 through 2009. The cohort included patients receiving morphine SR or methadone who were aged 30 to 74 years, did not have cancer or another life-threatening illness, and were not in a hospital or nursing home. At cohort entry, 32 742 and 6014 patients had filled a prescription for morphine SR or methadone, respectively. The patients’ median age was 48 years, 57.9% were female, and comparable proportions had received cardiovascular, psychotropic, and other musculoskeletal medications. Nearly 90% of the patients received the opioid for back pain or other musculoskeletal pain. The median doses prescribed for morphine SR and methadone were 90 mg/d and 40 mg/d, respectively.

Main Outcomes and Measures  The primary study end point was out-of-hospital mortality, given that opioid-related deaths typically occur outside the hospital.

Results  There were 477 deaths during 28 699 person-years of follow-up (ie, 166 deaths per 10 000 person-years). After control for study covariates, patients receiving methadone had a 46% increased risk of death during the follow-up period, with an adjusted hazard ratio (HR) of 1.46 (95% CI, 1.17-1.83; P < .001), resulting in 72 (95% CI, 27-130) excess deaths per 10 000 person-years of follow-up. Methadone doses of 20 mg/d or less, the lowest dose quartile, were associated with an increased risk of death (HR, 1.59; 95% CI, 1.01-2.51, P = .046) relative to a comparable dose of morphine SR (<60 mg/d).

Conclusions and Relevance  The increased risk of death observed for patients receiving methadone in this retrospective cohort study, even for low doses, supports recommendations that it should not be a drug of first choice for noncancer pain.  (more)


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